Endothelial dysfunction is an early predictor of cardiovascular disease and is the end-organ casual pathological mechanism of a variety of metabolic diseases, including any that lead to inflammation and resistance. Endothelial function has been shown to be impaired in people with coronary artery disease, type II diabetes, hypertension, obesity, renal failure, and hypercholesterolemia. Endothelial dysfunction is present in several systemic pathological conditions, associated with considerable morbidity and mortality. There are TONS of references. Please start accumulating them. Chris + Chad, this can/should begin with you and also Lauren and Vanessa, the Cis can help. I send many all the time. Now saved in Slack, but that is recent.
Normal endothelial function means that arteries function well, these is less resistant ‘in the pipes’ so-to-speak and blood flow is less impeded, and this has been shown to lead to less atherosclerosis (hardening of the arteries) and plaque build-up.